Children are most at risk with bacterium resistance
There are 32 children antibiotics in development around the world but only 12 can be considered innovative. And just 4 are active against at least one “critical” pathogen, i.e. those indicated in the WHO blacklist, the World Health Organization. The website www.rainews.it writes it.
The use of antibiotics becomes massive during flu peaks. The appeal a year ago by Andrea Mandelli, president of the Federation of the orders of Italian pharmacists: “Antibiotic is not a panacea”
The picture that comes fromWHO in a report on weapons against BPPL infections (Bacterial Priority Pathogens List), i.e. the bacteria considered most dangerous, he outlines a complex future for the fight against antibiotic-resistant infections. Infections resistant to antimicrobial drugs cause over 35,000 deaths in European countries every year and unfortunately about a third of these deaths occur in Italy.
The availability of products for is also problematic childrenin more convenient oral formulations for outpatients, and in agents to address growing drug resistance.
Antimicrobial resistance occurs when bacteriaviruses, fungi and parasites no longer respond to drugs, making people more vulnerable and increasing the risk of spreading difficult-to-treat infections, illnesses and deaths.
“Antimicrobial resistance is only getting worse, but we are not developing cutting-edge new products fast enough to fight the most dangerous and deadly bacteria,” Yukiko said Nakatani, WHO Deputy Director-General for Antimicrobial Resistance. “Innovation is sorely lacking but, even when new products are authorized, access is a serious challenge.”
“Antibacterial agents simply do not reach the patients who desperately need them, in countries of all levels income“.
Not only are there too few antibacterial in the pipeline, given the time needed for research and development and the likelihood of failure, but there isn’t even enough innovation.
“It is encouraging though that non-traditional biological agents, such as bacteriophages, antibodies, anti-virulence agents, immunomodulatory agents and modulating agents are increasingly being explored as complements and alternatives to antibiotics. However, studying and regulating non-traditional agents is not easy. Further efforts are needed to facilitate clinical trials and evaluations of these products, to help determine when and how to use these agents clinically.”
As far as news is concerned, it is mentioned the authorization of 3 non-traditional agents, all fecal-based products to restore the intestinal microbiota, to prevent recurrence of Clostridioides difficile infections (CDI) after antibiotic treatment in adults.
Antibiotics that are used in an excessive or too “easy” way – as well as during the flu peaks of the winter – often also during the holidays, in order to celebrate despite the illness, simultaneously leading – as Professor Pregliasco said a year ago – to excessive use of drugs.
The virologist’s warning Fabrizio Pregliasco: “One million Italians fell ill during the holidays. No to excessive medications just to celebrate.”
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