Scientists from the Mayo Clinic in the United States, together with their colleagues from the Netherlands and Germany, have created a vaccine based on a messenger RNA capable of healing bones. Scientific work described in Science Advances.
When damaged, human bone tissue is able to recover in two ways: direct formation from mesenchymal stromal cells (stem cells) or with the help of endochondral ossification, that is, through the formation of cartilage, which subsequently becomes ossified. At the same time, if these mechanisms fail, as well as other disorders in the body, the fractures do not grow together, which can even lead to amputation.
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Researchers have been able to develop a new way to treat such cases. It is based on the use of messenger RNA (ribonucleic acid), which is able to stimulate the restoration of bone tissue.
So far, scientists have tested the drug only on rats, but it has shown high efficacy and safety even when using a single dose.
In July, developers from Tomsk Polytechnic University (TPU) invented a technology that could speed up the recovery of damaged bones. They proposed using bioactive coatings on the surface of implants that were printed on a 3D printer.
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