“The age at which cold antibody autoimmune hemolytic anemia (CAD) is first diagnosed is generally “between 50 and 70 years old, but the onset” of the ultra-rare blood disease “probably occurs at a younger age.” The difficulty in diagnosis “delays it and therefore we have an incidence of the disease in the older population. The life expectancy of patients with Cad is clearly reduced, especially because there is still a lack of specific approved therapies”. She said it Antonella Sau of the Department of Hematology of the Ausl Pescara, speaking today in Rome at the presentation of 'A life without winter', the diary that recounts the desire of patients with Cad.
It is a “disabling” disease because it presents symptoms that are difficult to cure – explains the haematologist – i.e. asthenia, weakness, general malaise. Furthermore, these patients appear to be much more at risk of life-threatening thromboembolic events.” Characteristic of Cad is above all “chronic fatigue which is not only related to the degree of anemia but also to the pathogenesis of Cad, a profound asthenia that makes it difficult to carry out normal daily activities, including working”. Patients with CAD are “tired, anaemic, if they are exposed to the cold they have excruciating pain in the extremities of their hands and feet”, a condition “which often forces them to no longer leave the house, except in the hottest hours” he concludes.
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