A team of researchers has developed An organoid model derived from patients to observe how the trunk cells of the colon crypts -Cares glands- become the most common cell types of the colonic epithelium: enterocytes, which absorb water and nutrients, and mucousine-curse cells, which produce mucus to facilitate intestinal transit. This model allows an analysis in Biology depth and colon diseases.
In depth
The study has been led by the Chief of the Group of the Biomedical Cancer Research Center (CIBERONC), at the Sols-Morreale Biomedical Research Institute, Alberto Muñozand has been published in the magazine ‘Cell Death and Disease‘.
The study highlights the crucial role of Calcitriol, the active metabolite of the Vitamin din the maintenance of the trunk cells of the colonic epithelium in a more undifferentiated state, which is essential for the weekly renewal of the intestinal epithelium during adult life. In addition, in tumor colonic organoids, Calcitriol promotes cell differentiation, aligning with its antitumor effects already described in previous studies.
More details
“These findings underline The importance of maintaining adequate levels of vitamin D in the blood to prevent the deterioration of the colonic epitheliumrelated to inflammatory diseases such as ulcerative colitis and Crohn’s disease, “said the first author of the work and researcher of the Prof. Muñoz group, Pilar Bustamante-Madrid.
According to the researchers, This cellular differentiation model is also valuable for precision personalized medicine studiesbeing able to identify cancer treatments with less side effects.
To take into account
This work, in which the CIBERONC groups coordinated by Jaime Feliu (University Hospital Paz) and Francisco Xavier Real (National Center for Oncological Research, CNIO), has had the collaboration of Miguel Lafarga of the University of Cantabria-Idival.
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