The Government finally announced that Argentina will start to combine Sputnik V vaccine with AstraZeneca and Moderna. It is because the level of antibodies detected is similar to that found with two doses of the Russian vaccine. In the next few hours this will begin to be implemented throughout the country.
However, the response with one vaccine is not the same as with the other: it is already known that with the American protection will be superior than with Oxford. On the other hand, Moderna’s vaccine is the first that will be available to start implementing that combination.
This was confirmed by sources from the Buenos Aires government to Clarion. “The level of immunogenicity with the AstraZeneca vaccine is statistically similar the one achieved with the second component of Sputnik V, while with Moderna it is expected to be even higher ”, they explained.
There has not yet been time to measure the antibodies generated by Moderna’s vaccine, but the initial reaction it provoked in the volunteers, in terms of adverse effects – always mild – was superior. “That it’s a sign that the antibodies it develops are higher ”, said the sources consulted.
The presumption, based on available evidence, that Moderna’s vaccine performs better, is consistent with international studies in combination with another viral vector vaccine. That is, AstraZeneca as the first dose and Moderna or Pfizer (both messenger RNA) as the second. The Oxford technology is the same as that used by the Russian.
The AstraZeneca vaccine, an alternative to replace the Russian one. Photo: AFP
The worst performance in the combination trial was the Sinopharm vaccines, which were also part of the Buenos Aires clinical trial. “The level of antibodies achieved after a first dose of Sputnik it was not significant”Explained an expert with access to the results of the work.
The trial that was carried out in the City – whose conclusions will be published in a scientific journal – obtained its results by carrying out blood draws 28 days later work with volunteers started. “A similar level of antibodies from the point of view of cellular immunity gives us the guideline that the effectiveness of heterologous vaccination is equivalent to the counterpart ”. Two doses of Sputnik V give 92 percent effectiveness.
Based on these results, the City has already announced what the head of the Buenos Aires Government, Horacio Rodríguez Larreta, will publicly announce this Thursday morning: the start of the application of more than 150 thousand doses of Moderna, which is the remainder that the district will have after vaccinating minors with comorbidities. They expected 30 thousand boys between the ages of 12 and 17 to sign up and only 10 thousand signed up.
Before granting the turns they will send phone messages to people waiting for the second dose of Sputnik to ask if they agree to receive an alternative vaccine. In the City they are just over 100 thousand people those that have already passed 4 months without this supplement. That is to say that the doses of Moderna would be enough to vaccinate all the laggards of the Russian.
At the national level, there are more than a million personThey have already been waiting for the second component of Sputnik for a four-month period, which in principle could be covered by the remnant of Moderna doses, which is 1.7 million. That is to say that with that amount the Government would be “up to date”, at least with the most delayed.
Regarding the possibility of using AstraZeneca vaccines as second doses, first we have to wait that new batches arrive in the country. The last shipment, of less than a million vaccines, arrived in Argentina the last week of July. And there are still some 12 million doses for the total of 22.4 million of the signed contract.
Those doses will also have to be used, of course, with those awaiting the second dose of AstraZeneca. The interval between the first and second for that brand was set to two months. It will be necessary to see if the amount that arrives in the future will be enough to complete the schemes of the Oxford and, in addition, make up for the missing of the second component of Sputnik V.
If the announcements that were made from Russia in the last hours are fulfilled, during August the production of the second doses of the Russian vaccine would be normalized and they could begin to arrive in greater quantities in Argentina, with which the instance of have to choose to whom to allocate the AstraZeneca doses would become abstract. Moreover, if along with the latter the other announcement known this week is reflected: that the Richmond laboratory would contribute a good part of second doses of Sputnik V. to the cause.