I’m four the projects
selected by Fondazione Cariplo as part of the call for ‘Networking, research and training on the Post Covid Syndrome’, initiatives of the highest scientific value to which a total of 2 million euros are earmarked. Object of investigation of the four multidisciplinary research paths, the generation and dissemination of knowledge about Long-Covid, with an innovative approach in line with the guidelines set out in the Pnrr (National Recovery and Resilience Plan). “To support people who find themselves facing the development of pathologies in the long term, it is necessary to start again from the synergy between the subjects of the territory – says Giovanni Fosti, president of the Cariplo Foundation -. Collaboration is the keystone of a system which, both at national and local level, can favor the development of skills and models and which also stimulates the actors of the health system to work on shared and innovative projects “.
While the wave of infections does not seem to stop, despite the massive vaccination campaign of the Italian population has reached a coverage threshold of about 80%, in fact, the focus is on patients who have contracted Sars-Cov-2 infection in the past and who, after some time from recovery, present symptoms of various kinds that require health care. The survey published in ‘The Lancet’ in recent days has put the spotlight on the long-term consequences of Covid, often even in those who have not contracted the disease in a serious form. In the study to be compared are English patients who in the past contracted the infection and who today present a clinical picture attributable to the so-called long-covid, regardless of the variant with which they came into contact. A fact that had already been recorded by the German study Epilocwhich he had detected as the 20% of people between 18 and 25 years reported a moderate impairment of their health after the acute infection.
A set of pathologies, those that characterize post-covid cases, extremely varied: one goes dfrom dizziness to headaches, from sleep difficulties to shortness of breath, but also palpitations and irregular heartbeat up to neurological symptoms such as anxiety, stress, sweating and gastrointestinal disorders, skin rashes, muscle pains up to kidney problems and haematological disorders. To date, however, information and research on this front are still fragmented and insufficient to ensure a coordinated response by the national health systems for the thousands of subjects forced into highly disabling conditions.
The first of the four funded courses was born from these reflections, promoted by Asst Papa Giovanni XXIII in collaboration with the Italian Association of Anticoagulated Patients Bergamo Onlus, the Italian Association of Multiple Sclerosis Onlus, Asst Cremona, Asst Mantua, From-Foundation for Research Hospital of Bergamo and which aims to increase knowledge on the post-Covid condition (long-Covid) at more than one year of follow-up in the general population and in highly vulnerable subjects and share it with stakeholders. Although a significant percentage of patients with long-Covid can be expected to recover, no follow-up data beyond twelve months are available. Data on the long-term persistence of long-Covid will be extremely relevant to the strategic planning and management process of the health system.
A management that necessarily passes from the system of available information, as in the case of the project promoted by the Irccs Ca ‘Granda Foundation Ospedale Maggiore Policlinico in collaboration with Asst Spedali Civili di Brescia, Asst Santi Paolo and Carlo, Asst Grande Ospedale Metropolitano Niguarda, Istituto of Pharmacological Research “Mario Negri”, National Observatory on Women’s Health – Onda, Politecnico di Milano, University of Milan, which aims to collect the data already available on Long Covid and develop from these a platform in which all these data can be combined and interrogated to answer the questions elaborated by a panel of clinicians. The platform will allow for a mutual exchange of data, with real-time adjustments on clinical best practices. In addition, the platform will provide educational material for healthcare professionals and the general public and models for standard operating procedures that focus on local medicine.
And among the best practices, the ability to manage patients at home is certainly a priority with an integrated approach that keeps the patient at the center, and at the same time is able to properly lighten the hospital structure. This is the heart of the project promoted by the Fatebenefratelli Territorial Healthcare Company – Sacco of Milan in collaboration with the Asst di Melegnano and della Martesana, the Asst Rhodense, the Socio-Sanitaria Territoriale della Valtellina and Alto Lario , the Irccs Ca ‘Granda Foundation Ospedale Maggiore Policlinico, the Provincial Order of Surgeons and Dentists of Milan and the University of Milan.
Underlines Carlo Mango, director of the Scientific Research and Technology Transfer Area of the Cariplo Foundation: “The choice of the Cariplo Foundation is based on the need to circulate knowledge quickly and thoroughly and on the awareness that the syndrome can only be dealt with effectively thanks to a joint response capable of pooling data and knowledge. Furthermore, the launch of projects on this topic offers new opportunities to experiment with models of intervention that can be replicated to other affections and to develop useful skills to face the future challenges of the health system. In the health sector, as never before, knowledge and advanced technologies must be shared and put into a system to ensure prevention and accessible solutions for all. “
Access is possible only in the presence of a detailed and broad-spectrum analysis capable of looking at the current knowledge on the post-acute sequelae of Sars-Cov-2 infection from an epidemiological, clinical and public health perspective, in order to define a management protocol that takes into account diagnostic and management plans for the monitoring and management of the disease. In addition, the project, promoted by the Catholic University of the Sacred Heart in collaboration with numerous Asst of Lombardy, the University of Milan Bicocca and the University of Pavia, which will create a network between territorial social health agencies and cooperatives of medical doctors General, in fact, intends to evaluate the impact of the pandemic on the contraction in the provision of health services, in particular outpatient and screening ones, and on the management of assistance to fragile patients, in order to identify priorities for intervention, especially for subjects with chronicity or frailty.
A commitment, that of the Foundation on the Covid front, which has been renewed for the past two years with an extraordinary commitment of resources. From community funds to help people in need, to the Call with the Lombardy Region and the Veronesi Foundation to advance the knowledge of SARS-CoV-2, to the China / Italy humanitarian airlift to accelerate the influx of medical-health material from Beijing urgent, to the Qubì project to help people in severe economic difficulty, to participate in the Guarantee Fund of the Foundations (5 million euros) set up by Acri.
With the funding of the ‘Networking, research and training on Post Covid Syndrome’ projects, Cariplo maintains its commitment to scientific research: since 1991, in its thirty years of activity, whose celebrations occur in these days, the philanthropic body has supported 2,338 projects, equal to 538.1 million euros disbursed, in the fields of biomedical research, new technologies, agrifood and the circular economy. And again in social research, technical education and the enhancement of talents. In the field of scientific research alone, the Foundation has contributed to generating 6200 new researchers, 4225 publications in the most authoritative scientific journals and 68 registered patents.
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