It has long known that certain hormonal contraceptives are associated with a higher risk of stroke or stroke and cardiac infarction. Now, a macro -state that has reviewed the data of more than 2 million women in Denmark published in ‘The BMJ‘reinforces this evidence.
Specifically, higher risk estimates corresponded to contraceptives containing estrogen, in particular the toVaginal Nills and Cutane Patchesyou.
The researchers, coordinated by Harman Yonis, of the Nordsjaellands HospitalThey emphasize that the absolute risk remains low, but given the widespread use of these products and the severity of these conditions, they say that doctors should consider these potential risks to prescribe them.
It is estimated that almost 250 million women around the world use hormonal contraceptives. Previous studies have suggested a possible increase in the risk of ischemic stroke and heart attack with its use, but the results have been contradictory.
In addition, there is a lack of evidence about the effects of the different combinations of hormones, how they are taken (for example, pills, implants, injections, vaginal rings or skin patches) and for how long.
The study analyzed the prescription records of more than two million Danish women between 15 and 49 years between 1996 and 2021 to assess whether hormonal contraceptives increased the risk of stroke or infarction. Various methods were studied, such as combined pills, vaginal rings, patches, progestine pills, intrauterine devices, implants and injections. Women with a history of clots, cancer or other relevant medical conditions were excluded. In addition, factors such as age, educational level and pre -existing diseases were taken into account.
The results showed that: The combined estrogen and progestin pill doubled the risk of stroke and heart attack; The vaginal ring increased the risk of stroke 2.4 times and the infarction 3.8 times, and the patch raised the risk of stroke 3.4 times.
In addition, it was observed that only progestin contraceptives presented a lower risk, but still slightly high.
The intrauterine progestine system alone was the only option that did not increase the risk.
Risk & Benefits
Although researchers highlight that absolute risk remains low, emphasizes the importance of considering these effects by recalling contraceptives. “Doctors should include the potential risk of arterial thrombosis in their evaluation of benefits and risks,” they conclude.
These diseases are rare, especially in young women, says Therese Johansson, of the Swedish Technology Institutein a related editorial. However, “these side effects are serious and, since approximately 248 million women use hormonal contraceptives daily, the results have important implications.”
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