Scientists from the USA have proposed new ways to destroy cancer with the help of T-cells
A team of scientists from the Monash Biomedical Discovery Institute (BDI) in the US has proposed new ways to treat cancer. The identified checkpoint in T-cells responsible for immune defense has the potential. Work results published in Cancer Discovery magazine.
In a study on mice, the researchers found that by inhibiting (suppressing the activity of substances) a special tyrosine phosphatase protein PTP1B in T cells, the ability of immune defense is enhanced and can stop tumor development. The experiments were carried out using the drug by injection, which had previously proven its safety and effectiveness in humans.
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T cells are an important part of the body’s immune system, as they are able to destroy third-party pathogens such as viruses and cancer cells. However, it turned out that with an excess of the identified PTP1B proteins in T cells, the ability to attack tumor cells and fight oncology is reduced. Experts have designated such a phenomenon as an intracellular brake, or a checkpoint.
Scientists believe that the results of this work can form the basis of future clinical trials of drugs or cancer therapies.
Earlier, researchers at the University of Chicago created a small device that can detect tumor cells and make them visible to immune cells.
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