Medicine Researchers at the University of Helsinki found out why skin stem cells lose their vitality – The finding can help prevent baldness and skin aging

Connective tissue strengthening drugs would also help in wound healing.

As I get older the skin loses firmness and the hair becomes thinner. One reason for these signs of aging is that skin stem cells are no longer able to regenerate skin and hair.

Now researchers at the University of Helsinki have found out why stem cells are losing their vitality. The finding can help find ways to both prevent skin aging and hair loss and promote wound healing that deteriorates with age.

Helsinki Professor of Cell and Developmental Biology, University Sara Wickström and their groups focused their research on the stem cells of the hair follicles in the skin.

From the stem cells of the hair follicles, hair grows on our heads. As stem cells weaken with age, hair becomes thinner in both men and women.

In some cases, hair follicle stem cells also regenerate the skin. They take this action when a wound has entered the skin.

The connective tissue of the skin stiffens with age, which is visible on the top as wrinkles.

In their study in mice, Wickström and partners found that stem cells do not fatigue themselves. Instead, they cease to swell as the connective tissue surrounding them stiffens.

“When stem cells were transplanted into young mice, the ability of the stem cells to function was restored,” Wickström says.

Although the findings of the new study primarily concern hair follicles and hair aging, the same mechanisms are likely to affect other parts of the skin as well.

“We have preliminary results that connective tissue stiffening affects the entire skin.”

It has already been known in the past that the connective tissue of the skin stiffens with age, which appears on the top as wrinkles. Now, however, the researchers measured stiffness at the micro and nano levels. They showed that stiffening proceeds precisely in the environment of stem cells as well as consuming the ability of stem cells to regenerate.

Read more: Stress can cause hair to fall out because mental strain shakes the cells in the hair follicles

Can connective tissue strengthens with some constipation and helps stem cells stay in the steel, thus slowing the aging of the skin and hair? Wickström does not promise an immediate drug based on their research.

“We should study in human skin how connective tissue changes could be slowed or prevented. In the long run, one might think that there is a drug that could improve the situation. ”

A drug that prevents connective tissue damage would not only have the cosmetic function of saving against wrinkles or thinning hair. It could bring help to the chronic wounds that the elderly may suffer.

“Wound healing really slows down a lot in older people. It is the result of a decline in stem cell function. The important question is whether the aging of connective tissue could be slowed down and thus healing promoted. ”

Medicines While waiting, there is one real way to keep your skin’s connective tissue in good condition. It is worth remembering especially now in the summer, when there is an abundance of ultraviolet radiation.

“UV radiation affects connective tissue proteins. The most important inhibitor of skin aging is UV protection, ie the careful use of sunscreens. ”

According to Wickström, there is no joy in the cosmetics industry. According to him, there is no evidence that marketable wrinkle creams affect the molecular processes in the skin.

“Instead of people investing in anti-age products, sun protection is the most important thing.”

Wickström and his colleagues research published in the journal Nature Cell Biology.

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