Cuautitlan, Mex. Researchers from the Faculty of Higher Studies (FES) Cuautitlán produce insulin microcapsules for oral administration as an alternative to improve the quality of life of patients with diabetes.
The FES-Cuautitlán in a press release, this Friday announced the obtaining of the product in the Laboratory of Research and Postgraduate in Pharmaceutical Technology of the Faculty, a research space in charge of Dr. David Quintanar Guerrero.
He explained that doctors Quintanar, David Lechuga Ballesteros and teacher Diana Contreras Ortiz set themselves the goal, “to obtain enteric-coated microcapsules of a waterproof biodegradable polymer, that is, to cover the active ingredient with a substance capable of preventing the release of the drug until its arrival in the small intestine, where it is absorbed”, as a simple, efficient and comfortable administration alternative for the benefit of patients.
The active product is obtained from spray drying, developed in three steps: atomization, dehydration and dust collection. A peptide or protein solution is atomized in a drying chamber under a constant flow of hot air so that dehydration takes place in seconds. Due to the large specific area of the particles, this technique allows the formation of enteric microgranules or microparticles.
The oral administration of insulin originated as an initiative aimed at improving the quality of life of people with type one diabetes. In addition, it could mitigate some of the side effects that threaten the daily life of patients who do not administer the required injections.
“The most innovative thing about this implementation is that it integrates two knowledges of nanotechnology (bioadhesion and spray drying). For this reason, it can replace a standard injection treatment, offering multiple additional possibilities to pharmacological administration, since it can even work for vaccines administered nasally, pulmonaryly or vaginally”, explained the specialist.
It is worth mentioning that this non-invasive method meets all the requirements of the FDA (Food and Drug Administration): simple implementation, practical, stable during its storage period, adaptable to any drug, with better bioavailability and slow and controlled release, which allows maintaining the indicated therapeutic levels for a longer time.
In the statement it was announced that, throughout his professional career, Dr. Quintanar has coordinated various projects focused on improving public health, which has earned him the recognition of society and the university community, as well as of public and private organizations.
Recently, the Program for the Promotion of Patenting and Innovation (Profopi) awarded this latest proposal from the Research and Postgraduate Laboratory in Pharmaceutical Technology, with third place in its 2021 edition, positioning itself as one of the best patent applications.
This award is granted by the Coordination of Linkage and Technology Transfer (CVTT) and its purpose is to promote technological innovation, the culture of industrial property and technology transfer. With this, the university students show their capacity for application technology development and the relevance of their contributions to the area of nanotechnology.
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