New research conducted by a team of experts fromYale University proved that the calorie restriction brings interesting benefits to our health. In particular, the researchers recorded a reduction in the production of a protein called SPARC, with a consequent lowering of the inflammations that trigger aging.
The results of the study have been published in the scientific journal Immunity.
Calorie restriction: here are the benefits it brings to our body
The research, coordinated by Vishwa Deep DixitProfessor of Pathology of Waldemar Von Zedtwitz, Professor of Immunobiology and Comparative Medicine and Director of Yale Center for Research on Agingcomes after a study published earlier this year that indicated the main health benefits of moderate calorie restriction applied to humans.
In the new study, Dixit and his co-authors further investigated data from clinical research funded by the National Institutes of Health. In the study, known as a comprehensive assessment of the long-term effects of calorie restriction and thus of reduced energy intake, some volunteers who participated in the experiment reduced their calorie intake by 14% for two years, while others ate. as usual. The researchers then monitored the long-term health effects.
Specifically, Dixit and his colleagues analyzed study data to identify molecules responsible for the positive effects of calorie restriction and which could be targets for therapeutic treatment.
The researchers, who investigated any generic changes in the volunteers’ fat tissue after one and two years, found that those who turned on a calorie-restricted diet had reduced amounts of a protein called SPARC, or secreted protein. acidic and rich in cysteine, which has been linked to obesity, diabetes, and inflammation.
“Because inflammation plays such an important role in age-related decline, we wanted to better understand whether a pro-longevity intervention such as calorie restriction works through SPARC in controlling inflammation and immune responses,” Dixit said. Then, to delve into SPARC’s contributions to inflammation, the team of experts carefully analyzed the effects of the protein on mice’s immune cells and on the health of mice.
The researchers also revealed that the SPARC protein triggered inflammation by converting anti-inflammatory immune xells called macrophages into a pro-inflammatory state. However, reducing the production of SPARC by fat cells in the mice reduced inflammation, improved metabolism, prolonged their health, and slowed aging.
“The findings could lead to prevention of age-related decline,” Dixit explained: “We now have a better understanding of how SPARC protein affects inflammation and health by acting on macrophages and could be a useful target for inducing the health benefits of calorie restriction without actually having to change calorie intake, ”concluded the expert.
Eric RavussinPh.D., Associate Executive Director for Clinical Science at Pennington Biomedical Research Center, stated, “Two years of moderate calorie restriction have reprogrammed the pathways in fat cells that help regulate how mitochondria generate energy, the body’s anti-inflammatory responses and potentially longevity. In other words, calorie reduction rewires many of the metabolic and immune responses that increase lifespan and health span ”.
“As people get older, their thymes shrink and produce fewer T cells. As a result, older people find it more difficult to fight infections and some cancers. Calorie restriction helps prevent thymus shrinkage so that the person generates more T-cells, ”the expert added.
It is important to clarify that this article is for informational purposes only and does not intend to replace the work of distinguished medical specialists who have dedicated and dedicate their lives to the health of their patients. Undertaking a caloric restriction pathway means trusting a good specialist generally indicated by the family doctor.
Caloric reduction must be communicated balanced and rich in all nutrients and this balance so important for health can only be programmed together with a nutrition expert who will evaluate case by case whether it is necessary to reduce the calorie intake or continue with a normocaloric diet. , after evaluating the general state of health and all the parameters necessary to suggest to the patient whether to undertake a caloric restriction path or not.
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