A collaborative investigation between the University of Manchester and the National Institute for Health Research (NIHR) of the Manchester Biomedical Research Centerboth in the United Kingdom, shows that a new diagnosis of type 2 diabetes is associated with an increase posterior risk of developing some cancers related to obesity.
In depth
Previous research has described associations between type 2 diabetes mellitus (DM2) and a greater risk of several cancers related to obesity (Cro). However, it is not yet clear if these associations are causal, due to confusion factors (eg, their mutual risk factor, obesity); Immortal temporal bias (many studies combine the prevalent and new appearance DM2); o Temporary detection bias (for example, the joint diagnosis of two relatively common conditions at the same time). In this study, The authors set out to address these previous methodological deficiencies.
They carried out a cohort control study matched within the Biobanco of the United Kingdom of Diabetes type 2 of new appearance (defined by the date of the first diabetes not dependent on informed insulin) versus unplanned individuals paired (1 participant and 3 controls) in body mass index (BMI), age and sex. The primary result was the cro incident that covered Liver cancer, pancreas, intestine, postmenopausal breast, endometrium, kidney, esophagus, stomach, multiple myeloma, gallbladder, thyroid, meningioma and ovary.
When the number of cases allowed it, the authors also investigated the risk of localized cancers. A statistical model was used to calculate the greatest risk of cancer in participants with Type 2 diabetes, which was adjusted to alcohol consumption, smoking and the influx of cancer diagnoses shortly after the diagnosis of diabetes due to the increase in medical surveillance.
More details
A total of 23,750 participants with type 2 diabetes were matched with 71 123 controls. During a medium tracking of 5 years, 2431 new primary cancers were detected among the participants with Type 2 and 5184 Diabetes new primary cancers between the paired controls.
Data analysis showed that new appearance type 2 diabetes was associated with a 48 % increase in the risk of oral breast cancer (CRO) in men and 24 % in women, an independent effect of BMI. However, No associations with several specific localization cro were observed, In particular, endometrium cancer and postmenopausal breast cancer in women.
Positive associations were found: recent type 2 diabetes increased the risk of intestine cancer by 27 % in men and 34 % in women; The pancreas cancer in 74 % in men and almost double in women. As for liver cancer, Type 2 diabetes of recent appearance was associated with an almost four -time risk in men and almost five times in women.
The authors explain: “At this stage, we are not sure if these differences between men and women are due to a biological pathway dependent on sex, such as hormonal levels, insulin sensitivity, the composition of body fat, or a Simple difference in the amount of cancers found in men and women within the United Kingdom biobanco by chance“
To take into account
The authors conclude: “After considering the key biases found in previous research in this field and confusion factors (When adjusting the BMI, smoking, alcohol and detection time bias), our findings indicate that type 2 diabetes mellitus (DM2) of new appearance is associated with some, but not all, cancers related to obesity in specific sites. In turn, the ways by which DM2 can affect cancer related to obesity require greater research“
They add that several mechanisms are being investigated: high insulin levels (hyperinsulinemia), high glucose levels (hyperglycemia) and chronic inflammation. The authors claim: “Hyperinsulinemia presents the strongest evidence of a plausible mechanism due to its ability to stimulate cell growth and proliferation“
#investigation #demonstrates #link #appearance #type #diabetes #obesity #related #cancers
