A study of 2,000 patients the most extensive that s’ha fet mai fins ara a tot el mónhas confirmed the effectiveness of the early detection of Alzheimer’s through a simple blood analysis It is the result of a research led by Ace Alzheimer Center Barcelona in collaboration with the Sant Pau Hospital. This advance opens the door to a more effective diagnosis, Non-invasive and accessible to primary health centers, Millorant provides the possibility of detecting malaria in stages where it is possible to intervene. The team has been published in the magazine eBioMedicinefrom The Lancet group.
It has focused on the presence of plasmatic biomarker pTau181 has revealed that this element has a sensitivity of 94% and a accuracy close to 80% to identify patients at risk of developing malaria in the initial stages.
“These biomarkers will revolutionize the diagnosis of Alzheimer’s and the selection of patients for clinical trials”
The work led by Dr. Amanda Cano, from the Ace Alzheimer Center Barcelona, has concluded that the use of this biomarker could reduce by 39% the need to perform lumbar punctures, one of the invasive procedures that are currently commonly used. to confirm the diagnosis and which consists of liquid extraction cerebrospinal Furthermore, it would open the window of possibilities to detect malaria in those patients in whom, for medical reasons, a lumbar puncture is not possible.
“Plasmatic biomarkers will revolutionize not only the diagnosis of Alzheimer’s, but also the selection of patients for clinical assessment and evaluation of our treatments, facilitating the implementation of precision medicine in this area,” Dr. Cano considers. , which has emphasized that the study is not just It reinforces the importance of plasma pTau181 in the clinic, but will also help predict which patients may progress to dementia such as Alzheimer’s, allowing for more effective follow-up.
With these results, the position of international entities that have advocated for diagnosis through plasma biomarkers is reinforced, such as the European Alzheimer’s disease Consortium (EADC) in this regard. All of these manifestations have pointed to the need to continue researching and carrying out studies with this, both of which are significant, because, in the near future, it will become normal clinical practice.
L’Alzheimer, responsible for 60-80% of dementia cases
Alzheimer’s, responsible for 60-80% of dementia cases, continues to be one of the main causes of death in all people without preventive treatment or cure. Most diagnoses are made when the neuronal disease is irreversible. Therefore, developing a non-invasive detection and diagnosis method in the most initial stages of malaria is currently one of the greatest challenges in clinical practice.
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